Molecular Biology and Internet

Virtual Libraries


Digital information cycle:

  • Creation and capture
  • Storage and management
  • Rights management
  • Search and access
  • Distribution

  • Electronic publishing

  • Quality (peer review, retrospective evaluation)
  • Reliability (stability of serves, control over alterations, proper archiving and mirroring)

  • Hypertext Functionality in Scientific Literature



    Ethical, Legal, and Economical Issues of Electronic Publishing


    References:


    Writing for the Web.


    Scientific Bibliography

    UnCover
    UnCover is an online article delivery service, a table of contents database, and a keyword index to nearly 17,000 periodicals.

    SeqAnalRef: Sequence analysis bibliographic reference database
    SeqAnalRef is a bibliographic reference data bank relative to papers dealing with sequence analysis. This data banks stores the references of articles from the expanding field of mathematical and computer analysis of biomolecular sequences

    Search of the molecular biology subset of MEDLINE


    Publications

    BioMedNet: The World Wide Club For Biomedical Scientists On The Internet
    BioMedNet's Library offers members access to one of the world's largest collections of journals, monographs, books and databases, covering all areas of clinical medicine and modern biology. (Commercial)

    Complexity International
    An Electronic Journal of Complex Systems Research

    Journal of Biological Chemistry

    Journal of Computer-Aided Molecular Design

    Journal of Molecular Modeling

    Protein Science


    Databases

    Sequences:

    GenBank
    GenBank is the NIH genetic sequence database, a collection of all known nucleotide and protein sequences including supporting bibliographic and biological information. Entries include a concise description of the sequence, scientific name and taxonomy of the source organism, and a table of features specifying coding regions and other sites of biological significance.

    DNA Data Bank of Japan

    The EMBL Nucleotide Sequence Database
    The EMBL Nucleotide Sequence Database is a comprehensive database of DNA and RNA sequences collected from the scientific literature and patent applications and directly submitted from researchers and sequencing groups.

    PIR - The Protein Information Resource
    The Protein Identification Resource consists of an integrated computer system composed of a number of protein and nucleic acid sequence databases and software designed for the identification and analysis of protein sequences and their corresponding coding sequences.

    SWISS-PROT: Annotated protein sequence database
    SWISS-PROT is a curated protein sequence database which strives to provide a high level of annotations (such as the description of the function of a protein, its domains structure, post-translational modifications, variants, etc), a minimal level of redundancy and high level of integration with other databases

    PROSITE: Dictionary of protein sites and patterns
    PROSITE is a method of determining what is the function of uncharacterized proteins translated from genomic or cDNA sequences. It consists of a database of biologically significant sites, patterns and profiles that help to reliably identify to which known family of protein (if any) a new sequence belongs.

    NRL_3D
    NRL_3D is a sequence--structure database derived from the 3 dimensional structure of proteins deposited with the Protein Data Bank.

    Structures:

    PDB - Protein Data Bank
    The Protein Data Bank is an archival computer database of three-dimensional structures of biological macromolecules. The database contains atomic coordinates, bibliographic citations, primary sequence and secondary structure information, as well as crystallographic structure factors and 2D-NMR experimental data. Information is available on protein, DNA, RNA, virus and carbohydrate structures.

    The HSSP database
    HSSP (homology-derived structures of proteins) is a derived database merging structural (2-D and 3-D) and sequence information (1-D). For each protein of known 3D structure from the Protein Data Bank, the database has a file with all sequence homologues, properly aligned to the PDB protein.

    The DSSP program and database
    The DSSP database is a database of secondary structure assignments (and much more) for all of the entries in the Protein Data Bank (PDB).

    The FSSP database
    FSSP (families of structurally similar proteins) is a database of structural alignments of proteins in the Protein Data Bank (PDB). Each data set contains structural alignments of one search structure with all other structurally significantly similar proteins in the representative set

    GCRDb-WWW
    The G protein-Coupled Receptor DataBase

    3D_ALI
    The 3D_ALI databank is a collection of data which merges protein structural and sequence information. Structural superpositions amongst proteins with similar main-chain fold were performed or collected from the literature.

    Physical Data

    BioMagResBank
    The BioMagResBank database contains NMR chemical shifts derived from proteins and peptides, reference data, amino acid sequence information, and data describing the source of the protein and the conditions used to study the protein.

    BMCD: Biological Macromolecule Crystallization Database
    The Biological Macromolecule Crystallization Database (BMCD) contains crystals data and the crystallization conditions, which have been compiled from literature. BMCD include data on proteins, protein:protein complexes, nucleic acid, nucleic acid:nucleic acid complexes, protein:nulceic acid complexes, and viruses.

    QUEST 2D gel protein databases

    SWISS-2DPAGE: Two-dimensional polyacrylamide gel electrophoresis database
    SWISS-2DPAGE contains data on proteins identified on various 2-D PAGE reference maps. User can locate these proteins on the 2-D PAGE maps or display the region of a 2-D PAGE map where one might expect to find a protein from SWISS-PROT.