[Prev][Next][Index][Thread]
Re: WSN: hidrophobic/Van der Walls interactions energy...
From: kahn@ocelot.Rutgers.EDU
I am preoccupied with deadlines and cannot make a full reply to the
inquiry today. For the moment please note that the sickle cell hemo-
globin system is not as straightforward as it seems. Replacement of
the normal glutamate at the beta six position by valine does create a
hydrophobic patch on the surface of the protein. This causes the protein
to polymerize in a reversible entropy driven process. The normal protein,
however, does not polymerize, so the measurement of a free energy
difference between the normal and mutant proteins is not possible. This
complicates matters. It would be better to choose other systems to
examine
Peter Kahn